Cycloheptane Synthesis Essay

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  • Organic Chemistry Portal

    Reactions > Organic Synthesis Search

    Categories: C-C Bond Formation > Cyclic compounds > Cycloalkenes

    Synthesis of cycloheptenes and higher homologues


    Recent Literature

    The reaction of organocerium reagents, generated in situ from aryl and heteroaryl lithium compounds, with cycloalkanones proceeds cleanly to provide alkoxides. Addition of MsCl or SOCl2 with DBU gave aryl-substituted cycloalkenes in good yields. A short total synthesis of (±)-laurokamurene B is described.
    J. Tallineau, G. Bashiardes, J.-M. Coustard, F. Lecornué, Synlett, 2009, 2761-2764.

    In situ generation of allylic boronates by iridium-catalyzed borylation of cyclic alkenes in the presence of additives, such as methylimidazole and DBU, followed a reaction with aldehydes allows the synthesis of stereodefined homoallylic alcohols. Cycloalkenes without additives as well as acyclic substrates gave vinylic boronates, which were coupled with organohalides in a Suzuki-Miyaura sequence.
    V. J. Olsson, K. J. Szabó, J. Org. Chem., 2009, 74, 7715-7723.

    TFA-promoted exo carbocyclizations of nonterminal alkynals gave good to excellent yields of exo cycloalkenones. On the other hand, terminal 5-alkynals gave endo carbocyclizations to cyclohexenones. These carbocyclizations can be considered as tandem alkyne hydration/aldol condensation processes.
    C. González-Rodríguez, L. Escalante, J. A. Varela, L. Castedo, C. Sáa, Org. Lett., 2009, 11, 1531-1533.

    [ReBr(CO)3(thf)]2 catalyzes the reaction of a 1,3-dicarbonyl cyclic compound with an acetylene to give a medium-sized cyclic compound in excellent yield. By using isocyanide as an additive, the insertion of acetylenes into a carbon-carbon single bond occurs under mild conditions.
    Y. Kuninobu, A. Kawata, K. Takai, J. Am. Chem. Soc., 2006, 128, 11368-11369.

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